Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
نویسندگان
چکیده
منابع مشابه
Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus, ANA expression occurs commonly in healthy people. The basis for this expression is unknown, although it may reflect features of the assays for antibody detection or intrinsic immunological dis...
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Christopher Lieu, MD William J. Janssen, MD Sanjay Saint, MD, MPH Gurpreet Dhaliwal, MD 1 Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado. 2 Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado. 3 Ann Arbor Veterans Affairs Health Services Research and Development Center of Excellence, Ann Arbor, Michigan. 4 Patient Safety...
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Rheumatic heart disease (RHD) remains one of the largest preventable burdens of disease in the world. It is perceived as a disease of childhood, acquired by streptococcal throat infection of the tonsillo-pharynx, leading to an inflammatory reaction that involves many organs, including the heart. However, cases in children of 5 to 14 years of age are likely to represent only 15% to 20% of all ca...
متن کاملAnticardiolipin and antinuclear antibodies in the adult healthy Omani individuals.
OBJECTIVE To investigate the prevalence and normal versus abnormal levels of anticardiolipin antibodies (aCL) in a healthy adult population of Omanis and whether a correlation exists between aCL and antinuclear antibodies (ANA) in this Omani population. METHODS A total of 521 healthy Omani individuals (333 males and 188 females), aged between 17-54-years were investigated for the presence and...
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Park et al report in this issue of Blood that, despite the results reported in major clinical trials, the rate of early death (ED) in acute promyelocytic leukemia (APL) found in a population-based study remains high over the past 15 years.1 Based on data obtained from the US Surveillance, Epidemiology, and End Results (SEER) registry, the authors show that the ED rate for APL is not only consid...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2011
ISSN: 1478-6354
DOI: 10.1186/ar3282